"Psoriasis like" Reconstructed Human Epidermis

DESCRIPTION

The “Psoriasis like” Reconstrucetd Human Epidermis consists of normal human-derived keratinocytes cultured for 17 days at the air-liquid interface. To induce a diseased psoriatic phenotype, the model is cultured in a special culture medium. Thus, a metabolic active multilayered epidermal equivalent is formed in vitro wich is histological similar to psoriatic human epidermis.

The “Psoriasis like” RHE is characterized by a barrier function comparable to psoriatic skin and metabolic activity. The model can be employed for efficacy testing e.g. in vitro efficacy testing of topical formulation for the treatment of psoriasis. To ensure global availability, models are transported on an agarose based solidified medium mixed with Sterlab growth medium.

RECOMMENDED MEDIUM
Growth Medium (Ref: 205MILC – 125ml, 250ml or 500ml).

PRODUCT CHARACTERIZATION
Each production batch is provided with quality controls values and recommendations such as storage conditions, “Psoriasis like” RHE instruction for use, batch number and origin, histology, cell viability, barrier function integrity, absence of Hepatitis B, Hepatitis C, HIV, and Mycoplasma.

PRODUCT USE
The Sterlab “Psoriasis like” RHE model is for in vitro research use only and not for diagnostic or clinical applications.

APPLICATIONS

The “Psoriasis like” RHE can be employed to test the efficacy of pharmaceutical or cosmetic formulations for the treatment of psoriatic symptoms e.g. hydration level, anti-inflammatory activity or hyper-proliferation of keratinocytes.

Due to a dry surface, the “Psoriasis like” RHE allows realistic topical application scenarios for a broad range of liquid and solid substances. Moreover, a systemic application can be simulated by applying test substances into the culture medium.